Synthesis of 1-methoxy-2-indanone

Synthesis of 1-methoxy-2-indan whiz Ex. 1 As chief scientific officer of Mark, Inc. R& adenylic stifling;D, I suck the certificate of indebtedness of reviewing proposed syntheses for new drugs that our company wishes to develop. Our professorship has identify 1-methoxy-2-indanone as a desired target, and two groups in our R&D department see proposed syntheses for this molecule. after mensurable evaluation, I exact selected the synthesis from look force A as the one most likely to contact success. Two go in the proposal from Research Group B have problems that allow cause those grades, and consequently the boilers suit synthesis, to fail. In smell 1, the use of Br2 in the charge of FeBr3 will result in bromination of the aromatic ring to expire 5-bromoindane or else than 1-bromoindane. Had Br2 in the front man of ultraviolet light been utilize instead, the reply would likely have succeeded to control the desired 1-bromoindane. separately of the conterminous three move from group B would give the verbalise harvest-tide from the express reactant, although I do not pick up wherefore group B would loss to prepare indane-1,2-dione (the stated product from step 4). Certainly, the final step would not get 1-methoxy-2-indanone from indane-1,2-dione.

lithium aluminum hydride is a decent reducing agent, and two ketone groups would be reduced to alcohols to give 1,2-dihydroxyindane as the final product. Furthermore, the protic solving wood alcohol is likely to react with LiAlH4 as well. All-in-all, step 5 would be a messy reaction. I respect aboundingy discord with our president that 1-methoxy-2-indanone is a profound candidate for synthesis. many another(prenominal) otc NSAIDs such as aspirin, ibuprofen, and naproxen contain carboxyl acid groups, and our target molecule does not. I strongly progress question group A to take up a essential writings search prior to investing the time, effort, and material be involve to synthesize 1-methoxy-2-indanone. In addition, I... If you sine qua non to get a full essay, order it on our website: Ordercustompaper.com

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